Endocrine Abstracts

Temozolomide, an alkylating agent used in malignant gliomas, has been recently used too in the treatment of aggressive pituitary tumors. To date, two cases of Nelson’s syndrome has successfully treated with 5 days of 28-day cycle, but the follow-up has been shorter than 12 months. We reported the third patient with Nelson’s syndrome treated with temozolomide, who after an initial goal response to three 300 mg 5 days of 28-day cycles shown a clinical and biochemical (...

Purpose: IGF receptor 1 (IGF1R) and epidermal growth factor receptor (EGFR) are receptors tyrosine-kinase (RTK) whose altered signaling are critical factors in development of many types of tumours. These RTK are some of the main targets of the microRNA miR-7. This important tumor supressor miRNA has the ability to inhibit the motility, invasiveness and anchorage-independent growth, suggesting a strong therapeutic potential in many types of cancer. Pituitary adenomas (PA) are a...

Introduction: In primary hyperparathyroidism (PHPT) medical treatment is indicated if the patient donot carry out the surgical criterion, donot accept surgery or there is another serious comorbidity that makes impossible the intervention. Cinacalcet is a calcimimetic that increase the sensitivity of the calcium-sensing receptor (CaSR) to ionized serum calcium, decreasing secretion of PTH and serum calcium concentration. This drug is prescribed for secondary hyperparathyroidism...